Intracellular Glutathione Brain Breakthrough
Lori Hamilton and Dr. Corinne Allen
Copywritten 2010
 
 
What is the cause of Autism?
Recent research is clearly indicating that oxidative stress is a dominant factor in autism-spectrum disorders (ASD).  Dr. William Walsh, director of the Pfeiffer Treatment Center in Illinois, responsible for many key discoveries in his autism research such as undermethylation, mercury, lead, copper in brain tissues, abnormal hormone chemistry, and oxidation and low metallothioneine, has found there are many different genetic defects that can predispose a child to ASD by weakened protection against oxidative stress, rendering the brain vulnerable to toxic metals, viruses and other environmental insults.  The  results of such assaults on the brain can be destruction of brain cells, incomplete maturation of the brain, and onset of autism.  Oxidative stress has extensive harmful effects on the brain’s development, methylation, sulfur chemistry, the G.I. tract, protein digestion, and immune function.
 
 
Is Autism Genetically Caused?
According to extensive research by the Dr. Bill Walsh, the director of the Pfeiffer Treatment Center in Illinois, where they have amassed an autism database of more than 600,000 assays of biochemical factors, that involve more than 5,000 ASD subjects, the cause of Autism leaves little doubt that  there is a powerful genetic component.  This is in concordance with the studies on identical twins having 60-80% autism. One thing nearly everyone in the field agrees on: genetic predisposition.  Identical twins share the disorder 9 times out of 10.
But it is not 100% concordance for identical or monozygotic twins which implies that the environment must also be decisive in ASD disorders.  
 
How Can there be an epidemic of a genetic condition?
 
 The answer according to Dr. William Walsh of the Pfeiffer Treatment Center, is that there must have been a worsening in one or more environmental insults that predispose to autism.  There has been a dramatic increase in autism incidence throughout the world.  Think about your world and how it has changed in just the last five years.  Grade school children are carrying cell phones. Kids are on the computer, watching TV, or playing video games for hours a day exposing their fragile brain cells to damaging oxidative stress and free radical damage.  They are totally unprotected from the assaults of modern day living.  And this technological revolution is not getting better, every day kids and adults are more and more completely encased in an electrical, or microwave radiation. This is only one of the dramatic changes that we now experience in our world. Many more examples could be presented of the increases in toxicity in our food and environment.
 
We talk about Autism and those on the Autism Spectrum as being Epidemic, What does that really mean?
When we started our Advanced Learning & Development Institute brain center, the statistics from the CDC were 1 in 150 were on the autism spectrum seven years ago..  As of May, 2009 the CDC has released that 1 in 100 are on the Autism Spectrum and call  it an Autism Epidemic.  The incidence is 1:66 births in military families.  How long until there are MORE people ON the spectrum than people NOT on the spectrum???   This is the reason for this call. We need to wake up and take a hold of the answers that are at hand and be proactive in our health and the health of our children.  Since this is genetic we cannot sit idly by and just hope it won’t happen to you or your children’s children.
 
It has been found that a large factor in the cause of Autism has to do with high Mercury levels.  How Does this happen?
Research has shown that one of the big causes of autism is related to how mercury is removed in the system.  Mercury exposure causes oxidative stress or free radical production in the body and brain.
 A  potential breakthrough in the understanding of the etiology of autism occurred in 2003. Published in the International Journal of Toxicology,
7 researchers noted that hair analysis of autistic children showed a very significant reduction of mercury as compared to the hair analysis of normal children. The authors suggested that this could mean that normal children are efficient at removing mercury through mechanisms that include hair growth; in contrast, autistic children have a reduced ability to remove mercury from their bodies, increasing neurological damage.  Again we are looking at a possible genetic cause of this detoxification pathway being blocked or abnormal.
 
 
What are some of the signs of Mercury Poisoning?
Methylmercury: If a pregnant woman eats foods such as wheat, grains of all kinds, fish contaminated with methylmercury, the fetus is exposed to methylmercury. The main health hazard of methylmercury on fetus and infants is impaired neurological development. It also affects memory, cognitive ability, language as well as motor and visual spatial skills in children. Methylmercury can cause lack of coordination of movements, disturbances in sensations, impairment of peripheral vision, hearing and speech and muscle weakness. Exposure to inorganic mercury can damage the gastrointestinal tract, kidneys and nervous system. It can cause the symptoms such as memory loss, mental disturbances, mood swings, skin rashes and muscle weakness.
 
 
What are Sources of Mercury?
Whether we realize it or not mercury is one of the most common metals that we come into contact with daily.
Burning trash means that any plastics will be off gasing mercury vapors.  Fluorescent bulbs, off gas mercury, antibacterial soaps and chemical nonsoaps are high in mercury, dryer anit-cling sheets, kids shoes that light up, wheat, coal burning, dental fillings, fish, almost all grains are sprayed with fungicides heavily laced with mercury, automobile switches, cosmetics, water, shellfish, power plant emissions especially coal, gold and cement production.
 
Does glutathione have anything to do with Mercury detoxification?
 
Yes, in fact research tells us that autistics have trouble detoxifying metals like mercury and other chemicals.
             In 2004, researchers from the Department of Genetics at Arkansas Children’s Hospital in Little Rock noted that autistic children have reduced levels of the detoxifying antioxidant glutathione as compared to normal control children. The work of the lead researcher, S. Jill James was reviewed in Science News, April 16, 2005, noting that Biochemistry Blood Hints at Autism’s Source which Researchers have identified a biochemical peculiarity in the blood of autistic children.
 
 
Glutathione is known to be critical for detoxifying poisons like chemicals and heavy metals in the body.  How does this deficiency in glutathione relate to autism?
 
Dr. Jill Jame’s research found a pattern in autistics that they have an inability to detoxify poisons, especially heavy metals, such as mercury or lead. Glutathione is the antioxidant that normally binds to heavy metals and chemicals, and the body then targets the molecular complex for elimination..  Without sufficient glutathione in the cells these toxins cannot be taken out of the body. James suspects that autism develops under the combined effect of genetic mutations that deplete glutathione and exposure of a child to heavy metals or other poisons.
 
So could it be that the dramatic increase of autism in the last 15 years is due to Glutathione deficiency?
 
Dr S. Jill James, director of biochemical genetics at Arkansas Children’s Hospital in Little Rock. “Because genes don’t change that fast, this points to something in the environment as a trigger,” she says.
              James found an unusual biochemical fingerprint in the blood of 100% of 75 autistic kids, while none of 75 normal kids had the biochemical marker.
 
 
              “The autistic youngsters had unusually low concentrations of the antioxidant glutathione in their cells.”

Since autism is know to be strongly connected to genetics it is extremely important for the father and mothers to be taking high amounts of a glutathione supplement that can supply the brain and the body cells with continual glutathione to eliminate and detoxify free radicals which cause genetic DNA damage.  I believe that is our parents would take this seriously and every pregnant woman before and during pregnancy would take glutathione that we would start reversing this autism trend.
 
What is Gluthathione?
Glutathione is the body’s essential health protector and anti-aging resource. Glutathione is the master antioxidant, immune booster, and detoxifier.  There was a time when only scientists heard about glutathione.  Glutathione has been researched  for over 30 years, with over 70,000 Pub Med articles published on glutathione studies. But this research was not widely known by the public or the health professionals.   But now it is glutathione’s turn to get the spotlight and come out of the laboratory and become known as a common household word when talking about our health.

Every cell is the body is responsible for its own supply of glutathione and must have the raw materials to make it.  No matter what our lifestyles are, glutathione is always in great demand and rapidly consumed whenever we feel any sort of pressure, illness, stress, fatigue and even exercise. It is also well known that further depletion comes from drugs, poor diet, radiation, chemicals, pesticides, stress, injury, dental amalgams, trauma, etc. 

There are other antioxidants, that we are more familiar with like, Co Q10, Vit A, vitamin E, Vitamin C, SOD, and Catalase to name just a few. But all the other antioxidants depend upon the presence of glutathione to function properly.  This is why scientists call it the “master antioxidant.”    The immune system needs lots of glutathione to fight the attack from invaders like toxins, baterias, virus’, fungi, etc.,  by producing more white blood cells—the most important front line defense of the immune system.   Dr. Gustavo Bounous, leading glutathione expert says, “ The limiting factor in the proper activity of our lymphocytes (white blood cells) is the availability of glutathione.” So any and all problems with the immune system’s functioning are related to inadequate amounts of glutathione because our defense system which uses white blood cells cannot perform well without enough glutathione. 
 
What is the Main Souce of Glutathione in the body?
 
The main source of organ detoxification is in the liver.  The liver just happens to be the body’s most concentrated source of glutathione.  If there is not enough glutathione produced there will be little protection to keep toxins from circulating through the body and their subsequent damage to cells and organs.  Is it any wonder that God created the most important detoxification organ in the body, ie, the liver, to be the organ that needs high amounts of glutathione.  This is where the body concentrates the greatest sources.  If sources of glutathione are not adequate, then the liver, our gatekeeper for detoxifying pollutants that come into the body, cannot do its job efficiently.  If the glutathione in the liver is too low then pollutants cannot be neutralized, thus allowing them free access into the tissues, cells and organs which eventually cause disease.
 
Drugs, supplements and IV’ glutathione have been found to be mostly ineffective and not able to raise the body’ glutathione levels significantly or for any length of time.  Supplements of glutathione, including whey, cannot cross the digestion barrier of the stomach and end up being lost before they get to their destination.  IV glutathione is quickly used up and lost.  Drug sources of glutathione are synthetic and have unproved safety records.
 
IV glutathione has a half-life in the human blood plasma of about 1.6 minutes. It breaks down in 1-2 minutes and then need energy added to to to get into the cells.  We know that the liver is the organ which needs the most amounts of glutathione, yet the IV glutathione is absorbed primarily by the kidneys, which makes use of it, then the lungs, and other organs in lesser amounts.  Poor liver, it misses out on getting much glutathione from this source of glutathione.  IV glutathione is not directly very beneficial to the liver because the IV’s send the glutathione into the blood rather than remove it from the blood to be utilized in the organs. The structure of IV glutathione is not as readily absorbed by the cells as well. 
 
How do we solve these problems of getting the Glutathione into the cells with our current sources of Glutathione?
 
After more than 10 years of research, Dr. Robert Keller found a way to get glutathione into the cells without it being lost through the digestive barrier.  The most powerful way to raise glutathione is to use the tested and proven, patented formula in a product that is a glutathione accelerator which provides the precursors for the liver to produce high amounts of glutathione and sends it into all the cells. It also has the ability to cause glutathione to be made over and over many time.
 
How important is Glutathione in Mercury Toxicity?
 
The biochemical importance of glutathione is reviewed in the 2002 book by Jimmy Gutman, MD titled, Glutathione, Your Body’s Most Powerful Protector. Dr. Gutman points out that glutathione is not only our body’s most powerful detoxifier of mercury and other toxins (including drugs like Tylenol/ acetaminophen), but it is also the most important molecule in our anti-oxidant network that protects us from the dangers of free radicals.
 

What are causes of Oxidative stress and free radicals?
 
Since oxidative stress is one of the predominate things that is linked to the cause of Autism it is important that we understand what that is?  Oxidative stress such as mercury and other chemicals in universally administered vaccines, industrial pollutants in air and water, and even certain foods - act as catalysts that trigger the disorder.
 
Free radicals from  pesticides, pollution, toxic metals, mercury amalgam fillings, stress, cigarettes, alcohol, acid water (all bottled, RO, distilled and filtered waters are acid and therefore classified as free radicals), vaccines, drugs, air pollution, neurotoxins like TCP, MSG, aspartame, virus’, bacteria, molds and fungi, etc,  Microwaves, cell phones, TV’s, video games, computers, wireless phones and computers, all give off radiation that bombards the body and becomes a free radical and oxidative stress that must be detoxified in the brain and body.  If there are not enough high powered antioxidants then these cannot be detoxified and they create inflammation and even cell death.  Many times this results in brain cell death as well.
 
Recent research in the Silicone valley in California has reported autism and aspersers’ out of control. Something is going on when it is reported that a region has a higher than normal distribution of people on the autistic spectrum.  Think about this. Autism is genetically linked. The parents of autistic children in the Silicone valley are highly involved in  electromagnetic and microwave technology.  They my carry a cell phone on them at all times, even wear a blue ray on their ear for hours at a time.  They are likely to have satellite TV, remote controls for everything, cell phones and TV’s for each child which they keep by their beds at night.  Kids sit exposed to computer waves (free radicals) from their dads laps in infancy.  Then they are allowed to sit in front of the TV for hours, play computer video games, game boys ,computer everything.  Much of it wireless of course. No thought is given to the 24/7 bombardment of these waves on their brain cells or the inflammation that it is causing in parents and children alike. 
 
Perhaps this is one of the main factors that is contributing to the genetics.  The parents are so unprotected from electromagnetic and electrical bombardments in their brains that they are killing their brain cells and don’t know they are and have no education on how to repair or protect from this damage that they are producing this new generations of overwhelming amounts of autistic children.
 
We find in our brain camps that electromagetics, microwaves, and radiation have a very distinct affect of the behavior and functioning of all brain injured participants. We have no microwave ovens, and extremely minimal radiation sources that they can come in contact with while doing their two week brain and neuron reconnecting therapies. We teach them how to protect themselves from these waves lengths when they go back to their environments.
 
If the body is under oxidative stress it means that there are less antioxidants, especially like glutathione to stop or reduce the effects of oxidative stress which can cause cell death and even moderate oxidation can trigger cell death. This is especially important when looking at oxidative stresses that affect the brain because it can damage and destroy vital neurons and brain connections.
 
Once oxidative stressors as free radicals enter the system and brain, if they are not neutralized and detoxified they cause inflammation in the brain and cells.  If inflammation is left unchecked there is often a gradual loss of brain cells and mental retardation. 
 
What is the Answer for Oxidative stress and Free Radicals?
 
What is important to note here is that the solution is not to just “fix” the kids.  The parents must get help too.  Clean up your environments.  Stop the sodas, acid or positively charged water and other drinks that are not hydrating the body or brain, change your diet –eating organic and chemical and pesticide free food. Remove the electronics from your children’s lives.  When you do use them use them only with electromagnetic shielding and protection on the equipment and the body.  Learn ways to clean food that you cannot get organic. Learn ways to protect the brain and the body from the electromagnetic bombardments.
 
Learn which supplements will best protect you and take then every day and give them to your children.  We will never be totally able to live in an unpolluted environment.  In the process of changing old patterns, learning new ways and even after these new patterns and habits are established we must take protective supplements.  THE best and highest form of food supplement protection is glutathione.   In the past IV, Creams, and supplements have not been able to adequately assimilate into the liver and saturate all the cells with enough glutathione. But we have also never needed glutathione more than we need it now for our protection and our children’s protection and detoxification.
 
Dr. Robert Keller worked for 10 years to solve this problem.  He did. His breakthrough research found a way to produce a supplement that would conquer all of the problems with glutathione absorption, and also give the liver the precursors to produce its own glutathione naturally. 
 
What Else Does Intracellular Glutathione Do?
 
It does so many things that time limits us from telling you everything.  But here are just a few of the things it does; gives refreshing deeper sleep, supports even moods, supports repair or leaky gut, provides high energy to the cells engines called the ATP inside the mitochondria, reduces inflammation, increases endurance, supports increased energy, supports brain functioning for better cognition, speech, attention, memory and processing.  It strengthens natural hormones, reduces risk of illness by improving the immune system. It greatly slows down the aging factors, detoxifies the body and protects from all forms of oxidative stress and free radical damage.
 
But ONLY, and I emphasize ONLY, if you are getting enough glutathione are these things going to happen in you.  If you are not taking an absorbable glutathione than it is like being out in the New York cold winter stark naked.  You will be feeling the damaging effects of free radicals daily.  If you already take antioxidants make sure it is the best on the market.  It must be a glutathione accelerator and able to cross the digestive barrier.  Taking antioxidants and the right kind of antioxidant, glutathione is just the start.  You must take enough of the glutathione to not only neutralize what you are eating and doing daily but enough to get to the deep inflammation in the body and brain and  detoxify the chemicals, pesticides, radiation, and so many other forms of free radicals that are in the body.
 
Clean up your diet.  We see in autistics that the oxidative stress is so great that results are slowed greatly if toxic foods and environments are not changed dramatically.
 
What Do We See in Autistics when They receive this intracellular Glutathione supplement,  that actually crosses the digestive barrier?
 
In our Advanced Learning & Development Brain camps, which we conduct for 2 weeks at a time we see often miraculous changes in our participants.  We did not see as dramatic results before adding the best glutathione accelerator to our protocols.  We now see kids coming in who are having seizures every day, now on a glutathione accelerator we see almost a total absence of seizures.  We see Aspergers and autistics who are so low in energy that they won’t do anything all day long.  Yet we are able to do aggressive therapy for 6 hours a day, most of it is physical exercise.  Often they will stop reflex work or trampoline exercises and recharge their batteries with more glutathione 3-6 capsules at a time.  They  are quickly able to resume rigorous brain therapy with the glutathione reaching their cells almost instanteously. 
 
We often hear reports and see our clients improve in their speech.  They say things cleared and speak more words.  We see better sleep and calming in their behaviors.  We see better appetites and less aggression and sound sensitivity. 
 
Why is Glutathione so important to Making new Brain connections in the Advanced Learning & Development brain programs?
 
Science has found that by adding a cell-permeable glutathione to the brain it can increase the Neuronal (brain cell) glutathione by 250%.(Two-photon Imaging of Glutathione Levels in Intact Brain Indicates Enhanced Redox Buffering in Developing Neurons and Cells at the Cerebrospinal Fluid and Blood-Brain Interface* Journal of Biology Chemistry,  . Xiaojian Sun, Andy Y. Shih,  Helge C. Johannssen, Heidi Erb, Ping L and, Timothy H. Murphy, Supported by the Canadian Stroke Network and is an MSFHR Senior Scholar)
 
Science has confirmed that we do have the ability to grow new brain cells throughout all adulthood in humans and animals.   This process of growing new neuron or brain cells is called Neurogensis. One part of the brain involved with this neurogenesis is called the hippocampus.
 
When the brain grows new cells, new functions and learning also occur.  This is made possible by something scientists call Neuronal plasticity.   This enables the brain of animals and humans to adapt to environmental changes and influences learning and memory throughout life.
 
New and healthy brain cells don’t just happen. A number of different factors that regulate neurogenesis (the making of more new brain cells) have been identified including physical activity and environmental conditions which affect the proliferation and survival of neurons in animals and humans.  However, if there is a deficiency of glutathione in the brain it cannot grow and make new neurons. So the growth of new brain cells accentuated by the presence of high amounts of glutathione.
 
This is a major reason why in the Advanced Learning & Development Institute’s brain program client’s experience while doing specifically designed neurological physical movements, exercises and reflex movements see so many changes in functioning during and after the 2 week brain camp and home program.  During the program the participants require high doses of glutathione in the natural form of a glutathione accelerator while making untold number of new neurons and new connections which then become new movements, behaviors and thinking processes.   Glutathione is one of the most important nutritional supplements that the Advanced Learning & Development Institute uses in its brain recovery program.
 
 
What are the effects of Free Radicals, Oxidative stress, and Glutathione in Autism?
 
Autistic children have a significant decrease in the plasma concentration of glutathione which means they do not have the availability of the most important free radical scavenger in the cells.  This reduces their ability to lower oxidative stress and remove free radicals which cause DNA damage in the cells.
 
Autistic children have significantly increased oxidative stress in comparison to control children. This is relevant because glutathione is our body’s most powerful antioxidant that reduces oxidative stress.
 
 Glutathione is a necessary metabolite for the excretion of mercury from the body,  Without the necessary glutathione available in the cells of Autistics their bodies will have to deal with a larger Mercury burden, thereby increasing  neurodevelopmental disorders and oxidative stress
           
What are the amounts of glutathione that can be taken for children?
Children can take a little powder on the tip of their tongue if they are under 2 years old and have brain injury.  3-12 they can start with ? capsule and build to 3-5 a day.  Go slowly.  If their behavior worsens then they are in detox. This is usually the metals detoxifying.  Back down and work back up slowly.  Keep flushing a lot of alkaline (Kangen) water.
 
Once brain damage has occurred and a neurological problem exists, what along with  intracellular Glutathione supplementation can be done to bring help serious brain issues?
 
There is so much that is going on in the autistics.  They have immune, gut issues. They may have speech, behavior, cognition, socialization, learning, etc.  So a multi pronged approach must be under taken.